The most fundamental difference between Biblical Christianity and Roman Catholicism is the doctrine of salvation. The Bible clearly teaches that salvation is "by grace... through faith; and that not of yourselves: it is the gift of God: Not of works, lest any man should boast" (Ephesians 2:8-9). Salvation is a free gift received by faith alone in the finished work of Jesus Christ on the cross. Nothing can be added to it.
Roman Catholicism, however, teaches that salvation is a process requiring faith plus the sacraments (baptism, confirmation, Eucharist, penance, etc.), good works, and the ongoing merit of the church. The Council of Trent (1545-1563) explicitly condemned the doctrine of salvation by faith alone, declaring anathema on anyone who holds to it — a direct contradiction of Scripture.
The apostle Paul addressed this exact error in Galatians 2:16: "Knowing that a man is not justified by the works of the law, but by the faith of Jesus Christ." He further warned that adding anything to the gospel of grace perverts it into a false gospel (Galatians 1:6-9). The Roman Catholic system of merit and sacramental grace is precisely the kind of works-based addition Paul condemned.